Horny Goat Weed: MedlinePlus Supplements

29 Apr.,2024

 

Horny Goat Weed: MedlinePlus Supplements

Is it safe?

Check now

When taken by mouth: Horny goat weed extract is possibly safe when used short-term. A specific extract of horny goat weed containing phytoestrogens has been taken by mouth safely for up to 2 years. Another extract containing a chemical called icariin has been taken safely for up to 6 months.

But some types of horny goat weed are possibly unsafe when used for a long period of time or in high doses. Serious side effects including severe breathing problems have been reported.

Special precautions & warnings:

Pregnancy: Horny goat weed is possibly unsafe when taken by mouth during pregnancy. It might harm the developing fetus. Avoid using it.

Breast-feeding: There isn't enough reliable information to know if horny goat weed is safe to use when breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Horny goat weed might slow blood clotting. This might increase the risk of bleeding. Taking horny goat weed might make bleeding disorders worse.

Hormone sensitive cancers and conditions: Horny goat weed acts like estrogen and can increase estrogen levels in some people. Horny goat weed might worsen some estrogen-sensitive conditions, such as breast and uterine cancer.

Surgery: Horny goat weed might slow blood clotting. This might increase the risk of bleeding during surgery. Stop taking horny goat weed at least 2 weeks before surgery.

Horny Goat Weed: Health Benefits, Side Effects, Uses, ...

References

Chen, C. C., Huang, Y. L., Sun, C. M., and Shen, C. C. New prenylflavones from the leaves of Epimedium saggitatum. J Nat.Prod. 1996;59(4):412-414. View abstract.

Chen, C., Sha, M., Yang, S., and Zhang, Z. [Quantitative study of magnoflorine in Epimedium koreanum Nakai.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(11):681-2, 704. View abstract.

Chen, H. L., Wang, J. K., Zhang, L. L., and Wu, Z. Y. [Contents of general flavonoides in Epimedium acuminatum Franch. and its differently-processed products]. Zhongguo Zhong.Yao Za Zhi. 2000;25(4):239-241. View abstract.

Chen, K. M., Ge, B. F., Ma, H. P., and Zheng, R. L. The serum of rats administered flavonoid extract from Epimedium sagittatum but not the extract itself enhances the development of rat calvarial osteoblast-like cells in vitro. Pharmazie 2004;59(1):61-64. View abstract.

Chen, M. D., Kuang, A. K., and Chen, J. L. [Influence of yang-restoring herb medicines upon metabolism of thyroid hormone in normal rats and a drug administration schedule]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1989;9(2):93-5, 70. View abstract.

Chen, X., Zhou, M., and Wang, J. [Effect of epimedium sagittatum on soluble IL-2 receptor and IL-6 levels in patients undergoing hemodialysis]. Zhonghua Nei Ke.Za Zhi. 1995;34(2):102-104. View abstract.

Cheng, Q. L., Chen, X. M., and Shi, S. Z. [Effects of Epimedium sagittatum on immunopathology and extracellular matrices in rats with chronic renal insufficiency]. Zhonghua Nei Ke.Za Zhi. 1994;33(2):83-86. View abstract.

Chiba, K., Yamazaki, M., Umegaki, E., Li, M. R., Xu, Z. W., Terada, S., Taka, M., Naoi, N., and Mohri, T. Neuritogenesis of herbal (+)- and (-)-syringaresinols separated by chiral HPLC in PC12h and Neuro2a cells. Biol.Pharm Bull 2002;25(6):791-793. View abstract.

Dong, X. P., Xiao, C. H., Zhang, R., and Li, W. [Chemical studies of Epimedium acuminatum Franch]. Zhongguo Zhong.Yao Za Zhi. 1994;19(10):614-5, 639. View abstract.

Gao, B., Yu, J., and Xiao, P. [Chemical constituents from the aerial part of Epimedium brevicornum Maxim.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(5):290-2, 319. View abstract.

Guo, B. and Xiao, P. [Determination of flavonoids in different parts of five epimedium plants]. Zhongguo Zhong.Yao Za Zhi. 1996;21(9):523-5, 574. View abstract.

Guo, B., Yu, J., and Xiao, P. [Chemical constituents from the whole plant of Epimedium fargesii Franch.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(6):353-5, 383. View abstract.

Hu, B. H., Zhou, L. D., and Liu, Y. L. [Acuminatin from the aerial part of Epimedium acuminatum]. Yao Xue.Xue.Bao. 1992;27(5):397-400. View abstract.

Iinuma, M., Tanaka, T., Sakakibara, N., Mizuno, M., Matsuda, H., Shiomoto, H., and Kubo, M. [Phagocytic activity of leaves of Epimedium species on mouse reticuloendotherial system]. Yakugaku Zasshi 1990;110(3):179-185. View abstract.

Jia, X., Wu, J., and Mao, Q. [Chemical constituents of the root of Epimedium acumiantum Franch]. Zhongguo Zhong.Yao Za Zhi. 1998;23(3):162-4, 192. View abstract.

Kuroda, M., Mimaki, Y., Sashida, Y., Umegaki, E., Yamazaki, M., Chiba, K., Mohri, T., Kitahara, M., Yasuda, A., Naoi, N., Xu, Z. W., and Li, M. R. Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells. Planta Med 2000;66(6):575-577. View abstract.

Lee, M. K., Choi, Y. J., Sung, S. H., Shin, D. I., Kim, J. W., and Kim, Y. C. Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum. Planta Med 1995;61(6):523-526. View abstract.

Li, J., Lee, L., Gong, Y., Shen, P., Wong, S. P., Wise, S. D., and Yong, E. L. Bioassays for estrogenic activity: development and validation of estrogen receptor (ERalpha/ERbeta) and breast cancer proliferation bioassays to measure serum estrogenic activity in clinical studies. Assay.Drug Dev.Technol. 2009;7(1):80-89. View abstract.

Li, S. Y., Ping, G., Geng, L., Seow, W. K., and Thong, Y. H. Immunopharmacology and toxicology of the plant flavonoid baohuoside-1 in mice. Int J Immunopharmacol. 1994;16(3):227-231. View abstract.

Li, W. K., Pan, J. Q., Lu, M. J., Xiao, P. G., and Zhang, R. Y. Anhydroicaritin 3-O-rhamnosyl(1-->2)rhamnoside from epimedium koreanum and a reappraisal of other rhamnosyl(1-->2, 1-->3 and 1-->4)rhamnoside structures. Phytochemistry 1996;42(1):213-216. View abstract.

Li, W. K., Xiao, P. G., Tu, G. Z., Ma, L. B., and Zhang, R. Y. Flavonol glycosides from Epimedium koreanum. Phytochemistry 1995;38(1):263-265. View abstract.

Li, W. K., Zhang, R. Y., and Xiao, P. G. Flavonoids from Epimedium wanshanense. Phytochemistry 1996;43(2):527-530. View abstract.

Li, W., Guo, B., Xiao, P., Pan, J., Lu, M., and Zhang, R. [Chemical constituents of Epimedium wanshanense S. Z. He et Guo]. Zhongguo Zhong.Yao Za Zhi. 1996;21(10):614-6, 640. View abstract.

Liao, H. J., Chen, X. M., and Li, W. G. [Effect of Epimedium sagittatum on quality of life and cellular immunity in patients of hemodialysis maintenance]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(4):202-204. View abstract.

Liu, T. Z., Chen, C. Y., Yiin, S. J., Chen, C. H., Cheng, J. T., Shih, M. K., Wang, Y. S., and Chern, C. L. Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol. 2006;44(2):227-235. View abstract.

Ma, A., Qi, S., Xu, D., Zhang, X., Daloze, P., and Chen, H. Baohuoside-1, a novel immunosuppressive molecule, inhibits lymphocyte activation in vitro and in vivo. Transplantation 9-27-2004;78(6):831-838. View abstract.

Oh, M. H., Houghton, P. J., Whang, W. K., and Cho, J. H. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 2004;11(6):544-548. View abstract.

Sun, Y., Fung, K. P., Leung, P. C., Shi, D., and Shaw, P. C. Characterization of medicinal Epimedium species by 5S rRNA gene spacer sequencing. Planta Med 2004;70(3):287-288. View abstract.

chenlv contains other products and information you need, so please check it out.

Tan, X. and Weng, W. [Efficacy of epimedium compound pills in the treatment of the aged patients with kidney deficiency syndrome of ischemic cardio-cerebral vascular diseases]. Hunan.Yi.Ke.Da.Xue.Xue.Bao. 1998;23(5):450-452. View abstract.

Wang, T., Zhang, J. C., Chen, Y., Huang, F., Yang, M. S., and Xiao, P. G. [Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum]. Zhongguo Zhong.Yao Za Zhi. 2007;32(8):715-718. View abstract.

Wang, Y. K. and Huang, Z. Q. Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro. Pharmacol.Res 2005;52(2):174-182. View abstract.

Wang, Z. Q. and Lou, Y. J. Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Eur.J Pharmacol. 11-19-2004;504(3):147-153. View abstract.

Wei, S. Y., Zhang, P. X., Yang, D. M., Zhang, H. B., and Jiang, B. G. [Traditional Chinese medicine and formulas of improving peripheral nerve regeneration]. Zhongguo Zhong.Yao Za Zhi. 2008;33(17):2069-2072. View abstract.

Wu H, Lu Y Du S Chen W Wang Y. [Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes]. [Article in Chinese]. Zhongguo Zhong Yao Za Zhi. 2011;36(19):2648-2652.

Wu, B. Y., Zou, J. H., and Meng, S. C. [Effect of wolfberry fruit and epimedium on DNA synthesis of the aging-youth 2BS fusion cells]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(12):926-928. View abstract.

Wu, H., Lien, E. J., and Lien, L. L. Chemical and pharmacological investigations of Epimedium species: a survey. Prog.Drug Res 2003;60:1-57. View abstract.

Yamamoto, H., Ieda, K., Tsuchiya, S., Yan, K., Tanaka, T., Iinuma, M., and Mizuno, M. Flavonol glycoside production in callus cultures of Epimedium diphyllum. Phytochemistry 1992;31(3):837-840. View abstract.

Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. View abstract.

Yap, S. P., Shen, P., Butler, M. S., Gong, Y., Loy, C. J., and Yong, E. L. New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells. Planta Med 2005;71(2):114-119. View abstract.

Yin, X. X., Chen, Z. Q., Dang, G. T., Ma, Q. J., and Liu, Z. J. [Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts]. Zhongguo Zhong.Yao Za Zhi. 2005;30(4):289-291. View abstract.

Yong, E. L., Wong, S. P., Shen, P., Gong, Y. H., Li, J., and Hong, Y. Standardization and evaluation of botanical mixtures: lessons from a traditional Chinese herb, Epimedium, with oestrogenic properties. Novartis.Found.Symp. 2007;282:173-188. View abstract.

Zhao YL, Song HR Fei JX Liang Y Zhang BH Liu QP Wang J Hu P. The effects of Chinese yam-epimedium mixture on respiratory function and quality of life in patients with chronic obstructive pulmonary disease. J Tradit Chin Med. 2012;32(2):203-207.

Zhao, L., Lan, L. G., Min, X. L., Lu, A. H., Zhu, L. Q., He, X. H., and He, L. J. [Integrated treatment of traditional Chinese medicine and western medicine for early- and intermediate-stage diabetic nephropathy]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2007;27(7):1052-1055. View abstract.

Zhao, Y., Cui, Z., and Zhang, L. [Effects of icariin on the differentiation of HL-60 cells]. Zhonghua Zhong.Liu Za Zhi. 1997;19(1):53-55. View abstract.

Zheng, M. S. An experimental study of the anti-HSV-II action of 500 herbal drugs. J Tradit.Chin Med 1989;9(2):113-116. View abstract.

Anon. In vitro screening of traditional medicines for anti-HIV activity: memorandum from a WHO meeting. Bull World Health Organ 1989;67:613-8. View abstract.

Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.

De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. View abstract.

Liang, R. N., Liu, J., and Lu, J. [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28(4):314-317. View abstract.

Lin CC, Ng LT, Hsu FF, et al. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol 2004;31:65-9. View abstract.

Meng FH, Li YB, Xiong ZL, et al. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Phytomedicine 2005;12:189-93. View abstract.

Ning H, Xin ZC, Lin G, et al. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology 2006;68:1350-4. View abstract.

Parisi GC, Zilli M, Miani MP, et al. High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG). Dig Dis Sci 2002;47:1697-704.. View abstract.

Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. View abstract.

Phillips M, Sullivan B, Snyder B, et al. Effect of Enzyte on QT and QTc intervals. Arch Intern Med 2010;170:1402-4. View abstract.

Shen P, Guo BL, Gong Y, et al. Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry 2007;68:1448-58. View abstract.

Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. View abstract.

Yin XX, Chen ZQ, Liu ZJ, et al. Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2. Chin Med J (Engl) 2007;120:204-10. View abstract.

Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. View abstract.

Zhang G, Qin L, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone Miner Res 2007;22:1072-9. View abstract.

Zhang X, Li Y, Yang X, et al. Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation. Life Sci 2005;78:180-6. View abstract.

If you are looking for more details, kindly visit Epimedium Leaf Powder.