In recent years, Raman spectroscopy and imaging technology, benefiting from their superior spatial resolution and other advantages compared with infrared spectroscopy technology, have been widely used in studying the molecular vibration of samples, especially biological samples.
In recent years, Raman spectroscopy and imaging technology, benefiting from their superior spatial resolution and other advantages compared with infrared spectroscopy technology, have been widely used in studying the molecular vibration of samples, especially biological samples. However, Raman spectroscopy and imaging technology also have some shortcomings: (1) The lower Raman scattering cross section, especially in the fingerprint area, is 5-10 times weaker than infrared technology; (2) It will be interfered by fluorescence, and since the Raman signal is weak, the fluorescence signal of some samples is wide and strong and will cover the Raman signal to a certain extent.
Based on the optical-photothermal infrared technology (O-PTIR), the submicron resolution infrared Raman synchronous measurement system (mIRage) uses a wide tunable pulsed infrared laser source to excite the sample and produce a modulated photothermal effect in the sample. The infrared absorption is extracted and calculated by the photothermal effect, and the infrared absorption spectrum is provided by detecting the change of the beam intensity of the reflection probe as a function for infrared wave number tuning. This short-wavelength long-pulse probe beam determines the spatial resolution of the infrared test, rather than the infrared wavelength that traditional FTIR/QCL microscopes rely on. Due to its unique system architecture, the short-wavelength probe beam can also be used as a Raman laser source. When integrated with a Raman spectrometer, the mIRage system can provide the test results of submicron infrared + Raman microscopes with the same spatial resolution at the same place and at the same time.
The mIRage spectroscopy has the significant advantages of (1) Submicron spatial resolution consistent with Raman spectroscopy, 30 times higher than traditional FTIR/QCL microscopes, reaching 500 nm; (2) Non-contact measurement, non-destructive, reflection (far-field) pattern measurement, no complicated sample preparation; (3) High-quality spectrum (testing compatible with particle shape/size and surface roughness), no dispersion/scattering artifacts; (4) Matching search directly in commercial databases; and (5) Simultaneous measurement of infrared and Raman spectral imaging.
RESTON also provides different models of spectroscopy products, such as spectrometers and spectrophotometers.
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